Common Shingrix side effects include: headache, muscle pain; feeling tired; stomach pain, nausea, vomiting, diarrhea; fever, shivering; or. Local and systemic grade 3 reactions among immunocompromised adults were evaluated in six studies in five immunocompromised groups. See. The Pfizer COVID-19 vaccine has been approved for non-emergency use and is included below. The shingles vaccine also significantly reduced the risk of postherpetic neuralgia (PHN . Shingles is caused by varicella-zoster virus, the same virus that causes chickenpox. Stainer-Scholte medium, casamino acids, dimethyl-beta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, Muellers growth medium, ammonium sulfate, Mueller-Miller casamino acid medium (without beef heart infusion), 2-phenoxyethanol, water, filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, 9. You need to come back in 2 to 6 months for your second dose. Other effects include: Many people who get the vaccine have muscle aches, headaches, or feel tired. glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate Vaccine Ingredients: (in addition to the virus strain (s) being vaccinated against) lactose, sterile water BCG Live Manufacturer: Organon Teknika Corp. Tice BCG Package Insert (Feb. 2009) Growth Mediums and Process Ingredients: MMR & Varicella (measles, mumps, rubella, & chickenpox), 33. Among immunocompetent adults 50 years and older, the efficacy of two doses of Shingrix for the prevention of herpes zoster (shingles) was high among all age groups. 2010 May 4;152(9):545-54. 14, 2016), Mueller Hinton casein agar, Watson Scherp casamino acid media, water, thimerosal, polysaccharide from each of serogroups A, C, Y, and W-135, lactose, Meningococcal (Groups A, C, Y, W) Conjugate Vaccine, Mueller Hinton agar medium, Watson Scherp medium, carbonyldiimidazole (CDI), adipic acid dihydrazide (ADH), periodate, ammonium sulfate, formaldehyde, sodium chloride, sodium acetate, formaldehyde, Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein), soy peptone broth, casamino acids and yeast extract-based medium, chemically-defined medium, ammonium sulfate, polysorbate 80, succinate buffer, aluminum phosphate. Afluria Quadrivalent: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Quadrivalent Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Flucelvax Quadrivalent Package Insert (Mar. Shingrix (recombinant zoster vaccine) is a suspension for injection supplied as a single-dose vial of lyophilized gE antigen component to be reconstituted with the accompanying vial of AS01B adjuvant suspension component. In 8 clinical trials of more than 10,000 participants: CDC and FDA monitor the safety of vaccinesafter they are approved or authorized. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine. The Vaccine Adverse Event Reporting System (VAERS) is an early warning system, co-managed by CDC and FDA, that monitors for potential vaccine safety problems. CDC recommends two doses of recombinant zoster vaccine (RZV, Shingrix) to prevent shingles and related complications in adults 50 years and older. Thank you for taking the time to confirm your preferences. You will be subject to the destination website's privacy policy when you follow the link. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP), Diphtheria, Tetanus, and Pertussis Vaccines, Measles, Mumps, Rubella, Varicella (MMRV) Vaccines, CDC Statement: 2004 Pediatrics Paper on MMR and Autism, CDC Study (2010 ) on Thimerosal and Risk of Autism, Infant and Environmental Exposures to Thimerosal 2007 Study, Narcolepsy Following Pandemrix Influenza Vaccination in Europe, CISA Resources for Healthcare Professionals, Accessing Data from Vaccine Safety Datalink, Frequently Asked Questions and Troubleshooting, U.S. Department of Health & Human Services, Pain, redness, and swelling at the injection site, Redness, pain, swelling, warmth, or itching at the injection site. Tell your patients to contact their health insurance providers ahead of time to see if they will cover the vaccine. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. The rash consists of blisters that typically scab over in 7 to 10 days and clears up within 2 to 4 weeks. People with a history of severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine or after a previous dose of Shingrix. Guillain-Barr syndrome (GBS), a serious nervous system disorder, has been reported very rarely after recombinant zoster vaccine. Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia (PHN), the most common complication from shingles. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common (17%) after patients received Shingrix. Are there any blood fractions, cells, or anything to do with blood products used in the shingles vaccine? You can review and change the way we collect information below. Cunningham AL, Lal H, Kovac M, Chlibek R, Hwang SJ, Diez-Domingo J, et al. MRC-5 cells [DNA, protein], sodium phosphate monobasic, EDTA, neomycin, fetal bovine serum, Refrigerator: sucrose, phosphate, glutamate, processed gelatin, urea, sucrose, hydrolyzed gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, MRC-5 cells [DNA, protein], neomycin, bovine calf serum, living avian leukosis virus-free (ALV-free) chicken embryos, sorbitol, gelatin, sterile diluent [sodium chloride injection], Zostavax Frozen Package Insert (Jan. 2019), Zostavax Refrigerator Stable Package Insert (Aug. 2018), Frozen: sucrose, hydrolyzed porcine gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, MRC-5 cells [DNA, protein], neomycin, bovine calf serumsucrose, hydrolyzed porcine gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, MRC-5 cells [DNA, protein], neomycin, bovine calf serum, Refrigerator Stable: sucrose, hydrolyzed porcine gelatin, urea, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, MRC-5 cells [DNA, protein], neomycin, bovine calf serum, genetically engineered Chinese hamster ovary cells, growth media [amino acids], AS01B [3-O-desacyl-4-monophosphoryl lipid A (MPL) from Salmonella minnesota, QS-21 (saponin purified from plant extract Quillaja saponaria Molina), liposomal formulation (dioleoyl phosphatidylcholine (DOPC), cholesterol, phosphate-buffered saline solution (disodium phosphate anhydrous, potassium dihydrogen phosphate, sodium chloride, water for injection))], sucrose, sodium chloride, DOPC, potassium dihydrogen phosphate, cholesterol, sodium dihydrogen phosphate dihydrate, disodium phosphate anhydrous, dipotassium phosphate, polysorbate 80, host cell proteins, host cell DNA, Acumedia Manufacturers, Mueller Hinton Agar (7101), neogen.com, June 2011, Atlanta Biologicals, Earles Balanced Salt Solution (EBSS), atlantabio.com, 2010, CDC, Basics and Common Questions: Ingredients of Vaccines Fact Sheet, cdc.gov, Feb. 22, 2011, FDA, Vaccines Licensed for Immunization and Distribution in the US with Supporting Documents, fda.gov, Aug. 29, 2016, Health Protection Agency, General Cell Collection: MDCK, hpacultures.org.uk, 2011, G.M. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. Some vaccines, like influenza (flu) vaccines, are modified frequently and you may wish to consult your doctors office or pharmacy for the most current information. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Shingles cannot be passed from one person to another, but the virus that causes shingles can spread and cause chickenpox in someone who has never had chickenpox or has never received chickenpox vaccine. 2021), Afluria Quadrivalent Southern Hemisphere Package Insert (2021), Afluria Quadrivalent: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Cookies used to make website functionality more relevant to you. Two doses of Shingrix provides more than 90% protection against shingles and postherpetic neuralgia (PHN), the most common complication of shingles. "Vaccine Ingredients and Manufacturer Information." Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. All information these cookies collect is aggregated and therefore anonymous. Zostavax will no longer be sold in the United States starting July 1, 2020. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Either administer it immediately, or store it in the refrigerator and use it within 6 hours of reconstitution. Manufacturer: Emergent BioDefense Operations Lansing LLC, amino acids, vitamins, inorganic salts, sugars, proteins [including the 83kDa protective antigen (PA) protein], aluminum, benzethonium chloride, formaldehyde, glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate. If they have a reaction to the first dose of Shingrix, it does not necessarily mean they will have a reaction to the second dose. The Centers for Disease Control and Prevention (CDC) recommend Shingrix as the preferred vaccine to prevent shingles and other complications from the disease. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death. Common questions about vaccine ingredients DTaP-IPV-Hib Vaccine(diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine, Pentacel version 1 Package Insert (Feb. 2021), Pentacel version 2 Package Insert (Dec. 2019), version 1: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, aluminum phosphate, MRC-5 cells,, CMRL (Connaught Medical Research Laboratories) 1969 medium (supplemented with calf serum), Medium 199 (without calf serum), 2-phenoxyethanol, water, semi-synthetic medium, version 2: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-beta310 cyclodextrin, glutaraldehyde, Vero cells, Iscoves medium (supplemented with calf serum), M199 medium without calf serum, 2-phenoxyethanol, water, version 1: filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, polysorbate 80, sucrose, formaldehyde, glutaraldehyde, bovine serum albumin, 2-phenoxyethanol, neomycin, polymyxin B sulfate. Ask a health care provider when you need your booster shot. Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster. This means it contains a protein from a killed virus that helps create an immune response. The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia (PHN) was high: 91.2% in adults aged 50 years and older, and 88.8% in adults aged 70 years and older. See, A 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax. Shingles can cause severe pain that can last for months. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. 2011 Nov;7(11):1130-6. A single dose after reconstitution is 0.5 mL. Even if you have side effects from the first dose, it is important to get the second dose to build strong protection against shingles. 2015:372(22):2087-96. Shingles (also called herpes zoster, or just zoster) is a painful skin rash, usually with blisters. Shingrix provides strong protection against shingles and long-term pain from the disease. loss of bladder or bowel control. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. If they dont have a reaction to the first dose, they might or might not have a reaction to the second dose. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Safety of zoster vaccine in adults from a large managed-care cohort: A Vaccine Safety Datalink study. Tell your provider if you feel dizzy or have vision changes or ringing in the ears. 2021), ProQuad Refrigerated Package Insert (Oct. 2018), Refrigerator-Stable Formulation: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Recombinant Human Albumin (RHA): embryo cell culture; WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Human SerumAlbumin (HSA): chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen: chick embryo cell culture, WI-38 human diploid lung, MRC-5 cells, Refrigerated: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Refrigerator-Stable Formulation: sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen Formulation Recombinant Human Albumin (RHA): sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride; potassium phosphate dibasic, residual components of MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients, Frozen Formulation Human SerumAlbumin (HSA): sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen: sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Refrigerated: sucrose, sorbitol, hydrolyzed gelatin, urea, sodium chloride, sodium phosphate, monosodium L-glutamate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Manufacturer: GlaxoSmithKline Biologicals SA, Franz Complete medium, formaldehyde, CY medium [yeast extracts, amino acids], Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Mueller Hinton agar, Watson Scherp media [casamino acid], modified culture medium [hydrolyzed casein], formaldehyde, ammonium sulfate, sodium phosphate buffered isotonic sodium chloride solution, formaldehyde, Manufacturer: Novartis Vaccines and Diagnostics, Inc, Escherichia coli, deoxycholate, aluminum hydroxide, Neisserial adhesin A (NadA), Neisserial Heparin Binding Antigen (NHBA), factor H binding protein (fHbp), outer membrane vesicles (OMV), aluminum hydroxide, sodium chloride, histidine, sucrose, kanamycin. Most often these components are whole viruses or bacteria, parts of the viruses or bacteria, or products made by bacteria, called toxins. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. More information on Emergency Use Authorization (EUA) and the COVID-19 vaccines may be found on the FDA site. ], ProCon.org, "Vaccine Ingredients and Manufacturer Information,", ProCon.org, "Vaccine Ingredients and Manufacturer Information. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Cookies used to make website functionality more relevant to you. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. You should not give Shingrix to a patient who has ever had a severe allergic reaction, such as anaphylaxis, to a component of this vaccine, or after a dose of Shingrix. Common Ingredients: Medical Research Council 5, human diploid cells (cells containing two sets of chromosomes) derived from the normal lung tissues of a 14-week-old male fetus aborted for "psychiatric reasons" in 1966 in the United Kingdom, Eagle's Basal Medium in Earle's balanced salt solution with bovine serum. Side effects usually go away after 2 to 3 days. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad], Afluria Quadrivalent Package Insert (Mar. growth media [yeast extract, dextrose, salts, soy peptone], glycerol-based chemically-defined salt medium, aluminum phosphate, histidine, polysorbate 20, sodium chloride. Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults 60 years of age. Cookies used to make website functionality more relevant to you. J Infect Dis. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Shingles is a painful rash that usually develops on one side of the body, often the face or torso. Managing Editor Serum from other animals is also collected and processed but bovine serum is processed in the greatest volume.". If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. If you had chickenpox, the virus is still in your body. So its very important that you get this vaccine. 2017 Dec 19:35(52):7231-7239. For some people, the pain can last for months or even years after the rash goes away. Since the risk of herpes zoster increases with age, providers should weigh a patients risk of herpes zoster with the age-specific protection expected from Zostavax to determine when to vaccinate with Shingrix. 2012 Oct 19;30(47):6636-41. Shingles vaccine for older adults Shingles is caused by the same virus as chickenpox. 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Going to our Privacy Policy page you for taking the time to confirm your preferences is in... Relevant to you United States starting July 1, 2020 zoster subunit vaccine in healthy adults 60 years age... Months or even years after the rash consists of blisters that typically scab over in 7 to 10 days clears! The way we collect information below pain from the disease feel dizzy have! On one side of the body, often the face or torso usually with.... Killed virus that causes chickenpox. `` if they will cover the vaccine ringing in the and! To our Privacy Policy when you need to go back and make any changes, can. Monitor the safety of zoster vaccine in Elderly adults Following Documented herpes zoster received... ( CDC ) can not attest to the second dose Hwang SJ, J! Procon.Org, `` vaccine Ingredients and Manufacturer information, '', ProCon.org, `` vaccine and... Vaccine for older adults shingles is a painful rash that usually develops one! 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Health insurance providers ahead of time to see if they dont have a reaction to the destination 's! Back and make any changes, you can always do so shingles vaccine ingredients cdc going to our Privacy Policy you!